Pub. Date : 2014 Feb
PMID : 24332840
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Telaprevir is a substrate and moderate inhibitor of P-glycoprotein, a strong inductor of ABCG2, but not an activator of PXR in vitro. | telaprevir | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 2 | The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated. | telaprevir | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 3 | The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated. | telaprevir | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 4 | The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated. | telaprevir | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 5 | The in vitro potency of telaprevir to inhibit P-glycoprotein (P-gp, ABCB1) and breast cancer resistance protein (BCRP, ABCG2) was assessed and its substrate characteristics for P-gp, BCRP and the multidrug resistance-associated proteins (MRPs, ABCCs) 1-3 were evaluated. | telaprevir | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |
| 6 | In LS180 cells, telaprevir strongly induced mRNA expression of ABCG2 (4.3-fold at 30 mumol/L) and weakly induced ABCB11, CYP2C19 and UGT1A3. | telaprevir | ATP binding cassette subfamily G member 2 (Junior blood group) | Homo sapiens |