Pub. Date : 2013 Nov
PMID : 24331535
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Furthermore, resveratrol induced significant dephosphorylation of Akt, mTOR, p70S6K, and 4E-BP1, but enhanced specific phosphorylation of p38-MAPK which could be blocked by SB203580. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | CONCLUSION: Our findings have suggested that resveratrol induces cell cycle arrest, apoptosis, and autophagy in T-ALL cells through inhibiting Akt/mTOR/p70S6K/4E-BP1 and activating p38-MAPK signaling pathways. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |