Pub. Date : 1986 Dec 19
PMID : 2431720
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Incubation of the macrophages with heparin caused a marked increase in the secretion of lipoprotein lipase. | Heparin | lipoprotein lipase | Mus musculus |
| 2 | Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans). | Heparin | lipoprotein lipase | Mus musculus |
| 3 | The heparin-induced increase in lipoprotein lipase secretion was dependent on protein synthesis. | Heparin | lipoprotein lipase | Mus musculus |
| 4 | The secretion of lipoprotein lipase by macrophages in response to low levels of heparin may be a significant factor in the formation of atherosclerotic lesions. | Heparin | lipoprotein lipase | Mus musculus |