Pub. Date : 2014 Jul 1
PMID : 24310723
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of ATP citrate lyase induces triglyceride accumulation with altered fatty acid composition in cancer cells. | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 2 | ACLY depletion blocks the fatty acid chain elongation from C16 to C18 in triglyceride (TG), but not in other lipid classes. | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 3 | Meanwhile, wild-type ACLY overexpression enhanced fatty acid elongation of TG, whereas an inactive mutant ACLY did not change it. | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 4 | ACLY depletion-mediated blockade of fatty acid elongation was coincident with downregulation of long-chain fatty acid elongase ELOVL6, which resides in endoplasmic reticulum (ER). | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 5 | Consistent with this finding, metabolome analysis revealed that ACLY positively regulates the carnitine system, which plays as an essential cofactor for fatty acid transport across mitochondrial membrane. | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 6 | AICAR, an activator of mitochondrial fatty acid oxidation (FAO), significantly reduced ACLY depletion-mediated TG accumulation. | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 7 | These data indicate that inhibition of ACLY might affect both fatty acid elongation in ER and FAO in mitochondria, thereby explaining the TG accumulation with altered fatty acid composition. | Fatty Acids | ATP citrate lyase | Homo sapiens |
| 8 | These data indicate that inhibition of ACLY might affect both fatty acid elongation in ER and FAO in mitochondria, thereby explaining the TG accumulation with altered fatty acid composition. | Fatty Acids | ATP citrate lyase | Homo sapiens |