Title : Galectin-3 silencing inhibits epirubicin-induced ATP binding cassette transporters and activates the mitochondrial apoptosis pathway via β-catenin/GSK-3β modulation in colorectal carcinoma.

Pub. Date : 2013

PMID : 24303084






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1 We show for the first time that the silencing of galectin-3 sensitizes MDR cells to epirubicin by inhibiting ABC transporters and activating the mitochondrial pathway of apoptosis through modulation of the beta-catenin/GSK-3beta pathway in human colon cancer cells. Epirubicin catenin beta 1 Homo sapiens