Title : Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids.

Pub. Date : 2014 Jan 15

PMID : 24302004






2 Functional Relationships(s)
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1 Activation of AMPK by metformin inhibited mTORC1-STAT3 signaling, thereby preventing excess amino acid-impaired insulin signaling. Metformin CREB regulated transcription coactivator 1 Mus musculus
2 Chronic administration of either metformin or rapamycin inhibited the HPD-activated mTORC1/STAT3/Notch1 signaling pathway and prevented hepatic insulin resistance. Metformin CREB regulated transcription coactivator 1 Mus musculus