Title : Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model.

Pub. Date : 2014 Jun

PMID : 24297323






4 Functional Relationships(s)
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1 Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson"s model. Oxidopamine tyrosine hydroxylase Rattus norvegicus
2 In association with >80% TH loss, we observed a significant decrease in glutamate uptake in the established 6-hydroxydopamine (6-OHDA) PD model. Oxidopamine tyrosine hydroxylase Rattus norvegicus
3 In association with >80% TH loss, we observed a significant decrease in glutamate uptake in the established 6-hydroxydopamine (6-OHDA) PD model. Oxidopamine tyrosine hydroxylase Rattus norvegicus
4 increased striatal glutamate uptake with >5 consecutive days of injection in nonlesioned rats and lasted out to 14 days postinjection, a time beyond that required for 6-OHDA to produce >70% TH loss (~9 days). Oxidopamine tyrosine hydroxylase Rattus norvegicus