Title : The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins.

Pub. Date : 2014 Jan 17

PMID : 24292623






1 Functional Relationships(s)
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1 Analysis of myeloma cell lines revealed that loss of IKZF1 and IKZF3 is both necessary and sufficient for lenalidomide"s therapeutic effect, suggesting that the antitumor and teratogenic activities of thalidomide-like drugs are dissociable. Thalidomide IKAROS family zinc finger 1 Homo sapiens