Title : Glibenclamide improves kidney and heart structure and function in the adenine-diet model of chronic kidney disease.

Pub. Date : 2014 Jan

PMID : 24291534






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 NOD-like receptor protein-3 (NLRP-3) is pro-inflammatory in the kidney; glibenclamide inhibits production of NLRP-3. Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus
2 NOD-like receptor protein-3 (NLRP-3) is pro-inflammatory in the kidney; glibenclamide inhibits production of NLRP-3. Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus
3 Glibenclamide decreased infiltration of chronic inflammatory cells, fibrosis, tubular damage and expression of HO-1, TNF-alpha and NLRP-3 in the kidney. Glyburide NLR family, pyrin domain containing 3 Rattus norvegicus