Pub. Date : 2014 Feb
PMID : 24289814
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 2 | Genetic analysis of gene expression and behavior identified Chrna7 as potentially modulating nicotine place conditioning in the BXD panel of inbred mice. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 3 | We used gene targeting and pharmacological tools to confirm the role of Chrna7 in nicotine conditioned place preference (CPP). | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 4 | In the BXD panel, we found a putative cis expression quantitative trait loci (eQTL) for Chrna7 in NAc that correlated inversely to nicotine CPP. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 5 | In B6 mice, the alpha7 nicotinic acetylcholine receptor (nAChR)-selective agonist, PHA-543613, dose-dependently blocked nicotine CPP, which was restored using the alpha7 nAChR-selective antagonist, methyllycaconitine citrate (MLA). | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 6 | In B6 mice, the alpha7 nicotinic acetylcholine receptor (nAChR)-selective agonist, PHA-543613, dose-dependently blocked nicotine CPP, which was restored using the alpha7 nAChR-selective antagonist, methyllycaconitine citrate (MLA). | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |
| 7 | Mice lacking Chrna7 demonstrate increased insulin signaling in the NAc, which may modulate nicotine place preference. | Nicotine | cholinergic receptor, nicotinic, alpha polypeptide 7 | Mus musculus |