Title : Dual targeting of EWS-FLI1 activity and the associated DNA damage response with trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth.

Pub. Date : 2014 Mar 1

PMID : 24277455






1 Functional Relationships(s)
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1 Because WRN-deficient cells are known to be hypersensitive to camptothecins, we utilize trabectedin to block EWS-FLI1 activity, suppress WRN expression, and selectively sensitize Ewing sarcoma cells to the DNA-damaging effects of SN38. Trabectedin Fli-1 proto-oncogene, ETS transcription factor Homo sapiens