Pub. Date : 2014
PMID : 24274399
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PIM1 kinase as a target in prostate cancer: roles in tumorigenesis, castration resistance, and docetaxel resistance. | Docetaxel | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 2 | Furthermore, expression of PIM1 has been shown to be increased in prostate tissue after docetaxel exposure, conferring partial resistance to docetaxel. | Docetaxel | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 3 | Furthermore, expression of PIM1 has been shown to be increased in prostate tissue after docetaxel exposure, conferring partial resistance to docetaxel. | Docetaxel | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 4 | Correlatively, decreased PIM1 levels sensitize prostate cancer cells to docetaxel treatment. | Docetaxel | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 5 | Thus, PIM1 may be a target in docetaxel resistant disease. | Docetaxel | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |
| 6 | In summary, PIM1 kinase is involved in prostate tumorigenesis, castration resistance, and docetaxel resistance. | Docetaxel | Pim-1 proto-oncogene, serine/threonine kinase | Homo sapiens |