Title : BTK inhibition targets in vivo CLL proliferation through its effects on B-cell receptor signaling activity.

Pub. Date : 2014 Mar

PMID : 24270740






1 Functional Relationships(s)
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1 Furthermore, activities of BTK and phospholipase Cgamma2 as well as downstream signaling molecules, AKT and ERK, were all coordinately downregulated over time in ibrutinib-treated patients. ibrutinib AKT serine/threonine kinase 1 Homo sapiens