PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24270740-8	2014	Furthermore, activities of BTK and phospholipase Cgamma2 as well as downstream signaling molecules, AKT and ERK, were all coordinately downregulated over time in ibrutinib-treated patients.	ibrutinib	162-171	AKT serine/threonine kinase 1	Homo sapiens	100-103