Title : Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors.

Pub. Date : 2014 Jan

PMID : 24269511






1 Functional Relationships(s)
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1 SAR and docking studies allowed the identification of pharmacophoric groups for both kinases and demonstrated the importance of a hydrogen bond donor at the para position of the aniline moiety for interaction with conserved Glu and Asp amino acids in EGFR and VEGFR-2 binding sites. Hydrogen epidermal growth factor receptor Homo sapiens