Title : Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.

Pub. Date : 2013 Nov 27

PMID : 24268771






1 Functional Relationships(s)
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1 Combining the Bcl-2/Bcl-xL inhibitor ABT-737 with JAK2 inhibitors mediated prolonged disease regressions and cures in mice bearing primary human and mouse JAK2 mutant tumors. ABT-737 BCL2-like 1 Mus musculus