Pub. Date : 2014 Jan
PMID : 24266905
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: We tested the hypothesis that heparin administration prior to the emergence of tissue factor (TF) would increase plasma TF pathway inhibitor (TFPI) and attenuate TF-mediated thrombin generation during simulated cardiopulmonary bypass (CPB). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 2 | BACKGROUND: We tested the hypothesis that heparin administration prior to the emergence of tissue factor (TF) would increase plasma TF pathway inhibitor (TFPI) and attenuate TF-mediated thrombin generation during simulated cardiopulmonary bypass (CPB). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 3 | In the two TFPI boost groups, 50 U/kg of heparin was given to the donors intravenously five minutes before donation to boost plasma TFPI levels. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 4 | In the two TFPI boost groups, 50 U/kg of heparin was given to the donors intravenously five minutes before donation to boost plasma TFPI levels. | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 5 | The heparin-induced TFPI elevation reduced both thrombin-antithrombin complex and F1+2 to control levels in rTF + TFPI boost group (p = 0.0158 for thrombin-antithrombin complex, p < 0.0001 for F1+2 ). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 6 | The heparin-induced TFPI elevation reduced both thrombin-antithrombin complex and F1+2 to control levels in rTF + TFPI boost group (p = 0.0158 for thrombin-antithrombin complex, p < 0.0001 for F1+2 ). | Heparin | tissue factor pathway inhibitor | Homo sapiens |
| 7 | CONCLUSIONS: Heparin-induced TFPI elevation attenuates TF-mediated thrombin generation. | Heparin | tissue factor pathway inhibitor | Homo sapiens |