Pub. Date : 2013 Oct
PMID : 24259695
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DATA SYNTHESIS: Avanafil is a highly selective PDE5 inhibitor that is a competitive antagonist of cyclic guanosine monophosphate. | avanafil | phosphodiesterase 5A | Homo sapiens |
| 2 | Specifically, avanafil has a high ratio of inhibiting PDE5 as compared with other PDE subtypes allowing for the drug to be used for ED while minimizing adverse effects. | avanafil | phosphodiesterase 5A | Homo sapiens |
| 3 | A network meta-analysis comparing the PDE5 inhibitors revealed avanafil was less effective on Global Assessment Questionnaire question 1 while safety data indicated no major differences among the different PDE5 inhibitors. | avanafil | phosphodiesterase 5A | Homo sapiens |
| 4 | CONCLUSIONS: Avanafil is a potent PDE5 inhibitor and is an effective treatment option for ED. | avanafil | phosphodiesterase 5A | Homo sapiens |