Title : Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection.

Pub. Date : 2013 Dec

PMID : 24257399






2 Functional Relationships(s)
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1 We designed this investigation to examine whether ultra-low dose naloxone administered alone or in combination with morphine could alter the concentration of the excitatory amino acids (EAAs) glutamate and aspartate, as well as the expression of tumor necrosis factor-alpha (TNF-alpha) and its receptors (TNFR1 and TNFR2) in the spinal cord dorsal horn of rats with partial sciatic nerve transection (PST). Morphine tumor necrosis factor Rattus norvegicus
2 CONCLUSIONS: Ultra-low dose naloxone enhances the antihyperalgesia and antiallodynia effects of morphine in PST rats, possibly by reducing TNF-alpha and TNFR1 expression, and EAAs concentrations in the spinal dorsal horn. Morphine tumor necrosis factor Rattus norvegicus