Pub. Date : 2013 Nov 28
PMID : 24256730
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |
| 2 | Binding of these inhibitors to K-Ras(G12C) disrupts both switch-I and switch-II, subverting the native nucleotide preference to favour GDP over GTP and impairing binding to Raf. | Guanosine Triphosphate | KRAS proto-oncogene, GTPase | Homo sapiens |