Title : Cloned T-cell proliferation and synthesis of specific proteins are inhibited by quinine.

Pub. Date : 1986 Jul

PMID : 2425353






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 The potassium channel blocker quinine inhibited cell growth and the synthesis of p52 and p36 when added 0 or 2 hr after rIL-2 stimulation but not when added 6 hr after rIL-2 stimulation. Quinine interleukin 2 Rattus norvegicus
2 Thus, a quinine-sensitive event occurring in L2 cells between 2 and 6 hr after rIL-2 stimulation is necessary for synthesis of type II proteins, DNA synthesis, and cell proliferation. Quinine interleukin 2 Rattus norvegicus