Title : Impact of polymorphic variants on the molecular pharmacology of the two-agonist conformations of the human β1-adrenoceptor.

Pub. Date : 2013

PMID : 24250787






2 Functional Relationships(s)
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1 beta-blockers are widely used to improve symptoms and prolong life in heart disease primarily by inhibiting the actions of endogenous catecholamines at the beta1-adrenoceptor. Catecholamines adrenoceptor beta 1 Homo sapiens
2 The beta1-adrenoceptor also exists in two agonist conformations - a high affinity catecholamine conformation and a low affinity secondary agonist conformation. Catecholamines adrenoceptor beta 1 Homo sapiens