Title : Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.

Pub. Date : 2014 Feb

PMID : 24248601






1 Functional Relationships(s)
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1 These findings identify Grb2 as a new FAK activator and reveal its essential role in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration. Tyrosine growth factor receptor bound protein 2 Homo sapiens