Title : Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.

Pub. Date : 2013

PMID : 24223226






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1 Here we showed that human cancer cells, HepG2 and U2OS, cultured in medium containing BCAAs with Fischer"s ratio about 3, which was shown to have highest activities to synthesize and secrete of albumin, had higher activities to induce premature senescence and elevate mTORC1 activities. Amino Acids, Branched-Chain CREB regulated transcription coactivator 1 Mus musculus