Pub. Date : 2013
PMID : 24217647
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 2 | Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 3 | Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 4 | Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 5 | CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |
| 6 | CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. | Tyrosine | SRC proto-oncogene, non-receptor tyrosine kinase | Rattus norvegicus |