PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 185-188 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 185-188 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 207-210 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 35-38 24217647-7 2013 Furthermore, pretreatment with the Src-selective inhibitor, PP2, and shRNA targeted to Src or suppression of Rac1 with its selective inhibitor, NSC23766, blocked FAK phosphorylation at Tyr,(576/577) but not Tyr,(397) under periodic mechanical stress. Tyrosine 207-210 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 87-90 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 193-196 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 180-183 24217647-10 2013 CONCLUSION: Our findings collectively suggest that periodic mechanical stress promotes chondrocyte proliferation and matrix synthesis through at least two pathways, integrin beta1-Src-Rac1-FAK(Tyr(576/577))-ERK1/2 and integrin beta1-FAK (Tyr(397))-ERK1/2. Tyrosine 238-241 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 180-183