Pub. Date : 2014 Jan 10
PMID : 24214972
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramides and glucosylceramides are independent antagonists of insulin signaling. | Ceramides | insulin | Homo sapiens |
| 2 | Of particular note, ceramides antagonize insulin signaling in both myotubes and adipocytes, whereas glucosyceramides are only efficacious in adipocytes: 1) In myotubes exposed to saturated fats, inhibitors of enzymes required for ceramide synthesis enhance insulin signaling, but those targeting glucosylceramide synthase have no effect. | Ceramides | insulin | Homo sapiens |
| 3 | Of particular note, ceramides antagonize insulin signaling in both myotubes and adipocytes, whereas glucosyceramides are only efficacious in adipocytes: 1) In myotubes exposed to saturated fats, inhibitors of enzymes required for ceramide synthesis enhance insulin signaling, but those targeting glucosylceramide synthase have no effect. | Ceramides | insulin | Homo sapiens |
| 4 | 2) Exogenous ceramides antagonize insulin signaling in myotubes, whereas ganglioside precursors do not. | Ceramides | insulin | Homo sapiens |