Title : Exploring the potential of [11C]choline-PET/CT as a novel imaging biomarker for predicting early treatment response in prostate cancer.

Pub. Date : 2014 Jan

PMID : 24201549






4 Functional Relationships(s)
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1 RESULTS: The combination of NAD and RT-CAD significantly decreased tumour [C]choline uptake (SUV60,ave, SUV60,max, TMR60,max or Kimod-pat) and prostate-specific antigen (PSA) levels (analysis of variance, P<0.001 for all variables). nadide kallikrein related peptidase 3 Homo sapiens
2 A wide range of reduction in tumour SUV60,ave (38-83.7%) and SUV60,max (22.2-85.3%) was seen with combined NAD and RT-CAD despite patients universally achieving PSA suppression (narrow range of 93.5-99.7%). nadide kallikrein related peptidase 3 Homo sapiens
3 The reduction in tumour SUV60,ave after NAD was associated with PSA reduction (r=0.7, P=0.04). nadide kallikrein related peptidase 3 Homo sapiens
4 A differential reduction in [C]choline uptake despite a global reduction in PSA following NAD and RT-CAD could provide prognostic information and warrants further evaluation as an imaging biomarker in this setting. nadide kallikrein related peptidase 3 Homo sapiens