Title : Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib.

Pub. Date : 2014

PMID : 24200972






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lapatinib-resistant cells have an increased Src kinase activity and persistent levels of activation of ERK1/2 and AKT compared with parental cells. Lapatinib AKT serine/threonine kinase 1 Homo sapiens
2 Treatment with the Src inhibitor saracatinib in combination with lapatinib reduces AKT and ERK1/2 phosphorylation and restores the sensitivity of resistant cells to lapatinib. Lapatinib AKT serine/threonine kinase 1 Homo sapiens