Pub. Date : 2014
PMID : 24200972
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib. | Lapatinib | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Lapatinib-resistant cells have an increased Src kinase activity and persistent levels of activation of ERK1/2 and AKT compared with parental cells. | Lapatinib | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Treatment with the Src inhibitor saracatinib in combination with lapatinib reduces AKT and ERK1/2 phosphorylation and restores the sensitivity of resistant cells to lapatinib. | Lapatinib | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Taken together, our results demonstrate that breast cancer cells with acquired resistance to lapatinib have a more aggressive phenotype compared with their parental counterpart, and that Src signaling and CXCR4 play an important role in this phenomenon, thus representing potential targets for therapeutic intervention in lapatinib-resistant breast cancer patients. | Lapatinib | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 5 | Taken together, our results demonstrate that breast cancer cells with acquired resistance to lapatinib have a more aggressive phenotype compared with their parental counterpart, and that Src signaling and CXCR4 play an important role in this phenomenon, thus representing potential targets for therapeutic intervention in lapatinib-resistant breast cancer patients. | Lapatinib | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |