Title : Activities of multiple cancer-related pathways are associated with BRAF mutation and predict the resistance to BRAF/MEK inhibitors in melanoma cells.

Pub. Date : 2014

PMID : 24200969






1 Functional Relationships(s)
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1 We experimentally showed that TNFalpha, EGFR, IFNalpha, and IFNgamma pathway activities were also upregulated in melanoma cell A375 compared with its sub-line DRO, while DRO was much more sensitive to AZD6244 than A375. AZD 6244 epidermal growth factor receptor Homo sapiens