Pub. Date : 1986 Mar 5
PMID : 2419331
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor. | Cyclic AMP | insulin receptor | Homo sapiens |
| 2 | These results suggest that agents that raise intracellular cAMP increase phosphorylation of the insulin receptor on serine and threonine residues, reduce insulin-mediated receptor phosphorylation on tyrosine, serine, and threonine residues, and inhibit the insulin-dependent tyrosine protein kinase activity of the receptor. | Cyclic AMP | insulin receptor | Homo sapiens |
| 3 | Thus cAMP may attenuate insulin action by altering the state of phosphorylation of the insulin receptor. | Cyclic AMP | insulin receptor | Homo sapiens |