Pub. Date : 2014 Feb 15
PMID : 24189439
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Autocrine production of interleukin-6 confers ovarian cancer cells resistance to tamoxifen via ER isoforms and SRC-1. | Tamoxifen | interleukin 6 | Homo sapiens |
| 2 | Here we explore an association between IL-6 and TAM resistance. | Tamoxifen | interleukin 6 | Homo sapiens |
| 3 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 4 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 5 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 6 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 7 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 8 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 9 | We demonstrate that both exogenous (a relatively short period of treatment with recombinant IL-6) and endogenous IL-6 (by transfecting with plasmid encoding for sense IL-6) induce TAM resistance in non-IL-6-expressing A2780 cells, while deleting of endogenous IL-6 expression in IL-6-overexpressing CAOV-3 cells (by transfecting with plasmid encoding for antisense IL-6) promotes the sensitivity of these cells to TAM. | Tamoxifen | interleukin 6 | Homo sapiens |
| 10 | Further investigation indicates that TAM resistance caused by IL-6 is associated with the alteration of ERalpha, ERbeta and steroid hormone receptor coactivator (SRC)-1 expression levels, the protein interactions between SRC-1 and ERalpha, but not ERbeta, as well as blockage of estrogen-induced ER receptor nuclear translocation. | Tamoxifen | interleukin 6 | Homo sapiens |
| 11 | These results show that IL-6 secreted by OVCA cells may contribute to the refractoriness of these cells to TAM via ER isoforms and SRC-1. | Tamoxifen | interleukin 6 | Homo sapiens |
| 12 | Overexpression of IL-6 not only plays an important role in OVCA progression but also contributes to TAM resistance. | Tamoxifen | interleukin 6 | Homo sapiens |
| 13 | Our studies suggest that TAM-IL-6-targeted adjunctive therapy may lead to a more effective intervention than TAM alone. | Tamoxifen | interleukin 6 | Homo sapiens |