Title : Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

Pub. Date : 2013 Nov 5

PMID : 24189400






1 Functional Relationships(s)
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1 With the use of a drug network associated with the core network proteins, we identified two compounds, midostaurin and lestaurtinib, that could overcome drug resistance through direct EGFR inhibition when combined with erlotinib. midostaurin epidermal growth factor receptor Homo sapiens