Pub. Date : 2013 Nov 25
PMID : 24180640
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The molecular basis for the selectivity of tadalafil toward phosphodiesterase 5 and 6: a modeling study. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 2 | Great attention has been paid to the clinical significance of phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, tadalafil, and vardenafil widely used for erectile dysfunction. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 3 | Great attention has been paid to the clinical significance of phosphodiesterase 5 (PDE5) inhibitors, such as sildenafil, tadalafil, and vardenafil widely used for erectile dysfunction. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 4 | The present work reveals that tadalafil exhibits a less negative predicted binding free energy of -35.21 kcal/mol with PDE6 compared with the value of -41.12 kcal/mol for PDE5, which suggests that tadalafil prefers PDE5 rather than PDE6 and confers a high selectivity for PDE5 versus PDE6. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 5 | The present work reveals that tadalafil exhibits a less negative predicted binding free energy of -35.21 kcal/mol with PDE6 compared with the value of -41.12 kcal/mol for PDE5, which suggests that tadalafil prefers PDE5 rather than PDE6 and confers a high selectivity for PDE5 versus PDE6. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 6 | The present work reveals that tadalafil exhibits a less negative predicted binding free energy of -35.21 kcal/mol with PDE6 compared with the value of -41.12 kcal/mol for PDE5, which suggests that tadalafil prefers PDE5 rather than PDE6 and confers a high selectivity for PDE5 versus PDE6. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 7 | The present work reveals that tadalafil exhibits a less negative predicted binding free energy of -35.21 kcal/mol with PDE6 compared with the value of -41.12 kcal/mol for PDE5, which suggests that tadalafil prefers PDE5 rather than PDE6 and confers a high selectivity for PDE5 versus PDE6. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 8 | The binding free energy results for tadalafil were consistent with external bioassay studies (IC50 = 5100 and 5 nM toward PDE6 and PDE5, respectively). | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 9 | Two important residues from the Q2 pockets (Val782 and Leu804 in PDE5 and their corresponding Val738 and Met760 in PDE6) were further identified to account for the high selectivity of tadalafil for PDE5 versus PDE6. | Tadalafil | phosphodiesterase 5A | Homo sapiens |
| 10 | Two important residues from the Q2 pockets (Val782 and Leu804 in PDE5 and their corresponding Val738 and Met760 in PDE6) were further identified to account for the high selectivity of tadalafil for PDE5 versus PDE6. | Tadalafil | phosphodiesterase 5A | Homo sapiens |