Title : Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARĪ±) as a case study.

Pub. Date : 2014 Jan

PMID : 24180432






1 Functional Relationships(s)
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1 Chemical-specific and mechanistic data support concordance of temporal and dose-response relationships for the key events associated with many PPARalpha activators including a phthalate ester plasticizer di(2-ethylhexyl) phthalate (DEHP) and the drug gemfibrozil. Gemfibrozil peroxisome proliferator activated receptor alpha Homo sapiens