Title : An alternative explanation of hypertension associated with 17α-hydroxylase deficiency syndrome.

Pub. Date : 2014 Jan

PMID : 24176792






1 Functional Relationships(s)
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1 In humans, corticosterone and its 5alpha-Ring A-reduced metabolites are excreted via the bile into the intestine and transformed by anaerobic bacteria to 21-dehydroxylated products: 11beta-OH-progesterone or 11beta-OH-(allo)-5alpha-preganolones (potent inhibitors of 11beta-HSD2 and 11beta-HSD1 dehydrogenase). Corticosterone hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens