Title : Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors.

Pub. Date : 2014 Jul

PMID : 24172227






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors. oleandrin C-X-C motif chemokine ligand 8 Homo sapiens
2 Short-term exposure to oleandrin enhances responses to IL-8 by increasing cell surface IL-8 receptors. oleandrin C-X-C motif chemokine ligand 8 Homo sapiens
3 Here, we studied the effects of the plant glycoside oleandrin on responses to IL-8 in a human monocytic cell line. oleandrin C-X-C motif chemokine ligand 8 Homo sapiens
4 Pulse exposure to oleandrin increased expression of IL-8 receptors and chemotaxis, release of enzymes and activation of NF-kappaB, NFAT and AP-1 along with increased IL-8-mediated calcineurin activation, and wound healing. oleandrin C-X-C motif chemokine ligand 8 Homo sapiens
5 Pulse exposure to oleandrin increased expression of IL-8 receptors and chemotaxis, release of enzymes and activation of NF-kappaB, NFAT and AP-1 along with increased IL-8-mediated calcineurin activation, and wound healing. oleandrin C-X-C motif chemokine ligand 8 Homo sapiens
6 CONCLUSIONS AND IMPLICATIONS: Short-term (1 h; pulse) exposure to a toxic glycoside oleandrin, enhanced biological responses to IL-8 in monocytic cells, without cytoxicity. oleandrin C-X-C motif chemokine ligand 8 Homo sapiens