Title : Complexation and sequestration of BMP-2 from an ECM mimetic hyaluronan gel for improved bone formation.

Pub. Date : 2013

PMID : 24167632






3 Functional Relationships(s)
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1 To lower its effective dose, we precomplexed BMP-2 with the glycosaminoglycans (GAGs) dermatan sulfate (DS) or heparin (HP), prior to loading it into a hyaluronic acid (HA) hydrogel. Dermatan Sulfate bone morphogenetic protein 2 Rattus norvegicus
2 To lower its effective dose, we precomplexed BMP-2 with the glycosaminoglycans (GAGs) dermatan sulfate (DS) or heparin (HP), prior to loading it into a hyaluronic acid (HA) hydrogel. Dermatan Sulfate bone morphogenetic protein 2 Rattus norvegicus
3 Analysis of the kinetic interaction between BMP-2 and DS or HP showed that HP had approximately 10 times higher affinity for BMP-2 than DS, yet it equally stabilized the protein, as determined by alkaline phosphatase activity. Dermatan Sulfate bone morphogenetic protein 2 Rattus norvegicus