Pub. Date : 2013
PMID : 24155921
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We observed that LCK phosphorylated Tyr-342 of FOXP3 by immunoprecipitation and in vitro kinase assay, and the replacement of Tyr-342 with phenylalanine (Y342F) abolished the ability to suppress MMP9 expression. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 2 | Thus we demonstrate for the first time that LCK upregulates FOXP3 by tyrosine phosphorylation, resulting in decreased MMP9, SKP2, and VEGF-A expression, and suppressed cellular invasion. | Tyrosine | LCK proto-oncogene, Src family tyrosine kinase | Homo sapiens |