Title : Characterization of telmisartan-derived PPARγ agonists: importance of moiety shift from position 6 to 5 on potency, efficacy and cofactor recruitment.

Pub. Date : 2012 Nov

PMID : 24155042






1 Functional Relationships(s)
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1 Based on these findings, we designed and synthesized new PPARgamma ligands with a benzimidazole (agonists 4-5 and 4-6), benzothiophene (agonists 5-5 and 5-6) or benzofuran (agonists 6-5 and 6-6) moiety either at position 5 or 6 of the benzimidazole core structure. benzofuran peroxisome proliferator activated receptor gamma Mus musculus