Title : Novel path to IL-6 trans-signaling through thrombin-induced soluble IL-6 receptor release by platelets.

Pub. Date : 2013 Jul-Sep

PMID : 24152848






2 Functional Relationships(s)
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Protein Name
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1 IL-6R-alpha also exists as soluble protein (sIL-6R) that, in the presence of IL-6, forms a complex able to bind gp130 and, thanks to the mechanism called trans-signaling, transduces IL-6 effect through tyrosine phosphorylation and activation of the signal transducer and transcription activator (STAT)-3. Tyrosine interleukin 6 Homo sapiens
2 IL-6R-alpha also exists as soluble protein (sIL-6R) that, in the presence of IL-6, forms a complex able to bind gp130 and, thanks to the mechanism called trans-signaling, transduces IL-6 effect through tyrosine phosphorylation and activation of the signal transducer and transcription activator (STAT)-3. Tyrosine interleukin 6 Homo sapiens