Title : Arsenic augments the uptake of oxidized LDL by upregulating the expression of lectin-like oxidized LDL receptor in mouse aortic endothelial cells.

Pub. Date : 2013 Dec 15

PMID : 24145059






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1 Taken together, our results indicate that arsenic upregulates LOX-1 expression through the reactive oxygen species-mediated NF-kappaB signaling pathway, followed by augmented cellular oxLDL uptake, thus highlighting a critical role of the aberrant LOX-1 signaling pathway in the pathogenesis of arsenic-induced atherosclerosis. Arsenic nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus