Title : Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine 1-phosphate signaling pathway.

Pub. Date : 2013 Dec 15

PMID : 24134913






1 Functional Relationships(s)
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1 Fructose feeding induced hyperlipidemia, and activated SphK1/S1P signaling pathway characterized by the elevation of SphK1 activity, S1P production as well as SphK1, S1PR1 and S1PR3 protein levels, which in turn caused NF-kappaB signaling activation to produce IL-1beta, IL-6 and TNF-alpha and inflammation in the liver of rats. Fructose interleukin 6 Rattus norvegicus