Title : Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition.

Pub. Date : 2013 Dec

PMID : 24133029






2 Functional Relationships(s)
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1 RESULTS: HMGB1 signalling pathway components including receptors for HMGB1 as well as NF-kappaB and TNFalpha/VEGF were significantly upregulated in type 2 diabetic retinas and in high glucose treated ARPE-19 cells, compared to their respective counterparts. Glucose high mobility group box 1 Homo sapiens
2 HMGB1 blockage significantly alleviated NF-kappaB activity and VEGF secretion in ARPE-19 cells cultured with high glucose. Glucose high mobility group box 1 Homo sapiens