Pub. Date : 2013 Dec
PMID : 24130050
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma. | Tunicamycin | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 2 | The N-linked glycosylation (NLG) inhibitor tunicamycin dramatically reduced ABCG2 expression, altered its subcellular localization, and reversed its drug efflux effect in multiple hepatocellular carcinoma cell lines. | Tunicamycin | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 3 | Tunicamycin combined with cisplatin (CDDP) inhibited proliferating cell nuclear antigen (PCNA) expression and increased the cleavage of PARP; this effect was partially rescued by the overexpression of ABCG2 or Akt-myr. | Tunicamycin | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |
| 4 | In summary, our results suggest that tunicamycin may reverse the drug resistance and improve the efficacy of combination treatments for hepatocellular carcinomas by targeting the DPAGT1/Akt/ABCG2 pathway. | Tunicamycin | ATP binding cassette subfamily G member 2 (Junior blood group) | Mus musculus |