Title : Target hopping as a useful tool for the identification of novel EphA2 protein-protein antagonists.

Pub. Date : 2014 Jan

PMID : 24115725






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Lithocholic acid (LCA), a physiological ligand for the nuclear receptor FXR and the G-protein-coupled receptor TGR5, has been recently described as an antagonist of the EphA2 receptor, a key member of the ephrin signalling system involved in tumour growth. Lithocholic Acid EPH receptor A2 Homo sapiens
2 Lithocholic acid (LCA), a physiological ligand for the nuclear receptor FXR and the G-protein-coupled receptor TGR5, has been recently described as an antagonist of the EphA2 receptor, a key member of the ephrin signalling system involved in tumour growth. Lithocholic Acid EPH receptor A2 Homo sapiens
3 Given the ability of LCA to recognize FXR, TGR5, and EphA2 receptors, we hypothesized that the structural requirements for a small molecule to bind each of these receptors might be similar. Lithocholic Acid EPH receptor A2 Homo sapiens