Pub. Date : 2013 Nov
PMID : 24115572
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 2 | Here, we provide genetic and pharmacological evidence showing that p38 MAPK inhibition cooperates with the chemotherapeutic agent cisplatin to kill tumour cells. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 3 | We show that p38 MAPK inhibition results in ROS upregulation, which in turn activates the JNK pathway via inactivation of phosphatases, sensitizing human tumour cells to cisplatin-induced apoptosis. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |
| 4 | Taken together, our results illustrate a new function of p38 MAPK that helps tumour cells to survive chemotherapeutic drug treatments, and reveal that the combination of p38 MAPK inhibitors with cisplatin can be potentially exploited for cancer therapy. | Cisplatin | mitogen-activated protein kinase 14 | Homo sapiens |