Pub. Date : 2014 Jan
PMID : 24111524
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol prevents cadmium-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Furthermore, pre-treatment with celastrol prevented Cd down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and activation of phosphoinositide 3"-kinase/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling in neuronal cells. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Furthermore, pre-treatment with celastrol prevented Cd down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and activation of phosphoinositide 3"-kinase/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling in neuronal cells. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | Over-expression of wild-type PTEN enhanced celastrol inhibition of Cd-activated Akt/mTOR signaling and cell death in neuronal cells. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | The findings indicate that celastrol prevents Cd-induced neuronal cell death via targeting JNK and PTEN-Akt/mTOR network. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | This study underscores that celastrol prevents Cd-induced neuronal apoptosis via inhibiting activation of JNK (c-Jun N-terminal kinase) and Akt/mTOR network. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 7 | Celastrol suppresses Cd-activated Akt/mTOR pathway by elevating PTEN (phosphatase and tensin homolog). | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |