Pub. Date : 2013 Oct 9
PMID : 24107942
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we establish an essential role for SIRT1 and SIRT2 in regulating behavioral responses to cocaine and morphine through actions in the nucleus accumbens (NAc), a key brain reward region. | Cocaine | sirtuin 2 | Mus musculus |
| 2 | We show that chronic cocaine administration increases SIRT1 and SIRT2 expression in the mouse NAc, while chronic morphine administration induces SIRT1 expression alone, with no regulation of all other sirtuin family members observed. | Cocaine | sirtuin 2 | Mus musculus |
| 3 | Viral-mediated overexpression of SIRT1 or SIRT2 in the NAc enhances the rewarding effects of both cocaine and morphine. | Cocaine | sirtuin 2 | Mus musculus |